IFNG, interferon gamma, 3458

N. diseases: 167; N. variants: 1
Source: CURATED ×
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0549463
Disease: X-Linked Lymphoproliferative Disorder
X-Linked Lymphoproliferative Disorder 		0.330 Biomarker disease CTD_human Inorganic arsenic represses interleukin-17A expression in human activated Th17 lymphocytes. 22617429 2012
CUI: C0042963
Disease: Vomiting
Vomiting 		0.300 Biomarker phenotype CTD_human Hyponatremia and other toxic effects during a phase I trial of recombinant human gamma interferon and vinblastine. 3091246 1986
CUI: C0086541
Disease: Urban cutaneous leishmaniasis
Urban cutaneous leishmaniasis 		0.310 Biomarker disease CTD_human Clinical healing of antimony-resistant cutaneous or mucocutaneous leishmaniasis following the combined administration of interferon-gamma and pentavalent antimonial compounds. 8154019 1994
CUI: C0086541
Disease: Urban cutaneous leishmaniasis
Urban cutaneous leishmaniasis 		0.310 Therapeutic disease CTD_human Evaluation of localized and systemic immune responses in cutaneous leishmaniasis caused by Leishmania tropica: interleukin-8, monocyte chemotactic protein-1 and nitric oxide are major regulatory factors. 20102417 2010
CUI: C0086541
Disease: Urban cutaneous leishmaniasis
Urban cutaneous leishmaniasis 		0.310 Biomarker disease CTD_human Evaluation of localized and systemic immune responses in cutaneous leishmaniasis caused by Leishmania tropica: interleukin-8, monocyte chemotactic protein-1 and nitric oxide are major regulatory factors. 20102417 2010
CUI: C0086541
Disease: Urban cutaneous leishmaniasis
Urban cutaneous leishmaniasis 		0.310 Biomarker disease CTD_human Successful therapy of chronic, nonhealing murine cutaneous leishmaniasis with sodium stibogluconate and gamma interferon depends on continued interleukin-12 production. 9234779 1997
CUI: C0086541
Disease: Urban cutaneous leishmaniasis
Urban cutaneous leishmaniasis 		0.310 Therapeutic disease CTD_human Successful therapy of chronic, nonhealing murine cutaneous leishmaniasis with sodium stibogluconate and gamma interferon depends on continued interleukin-12 production. 9234779 1997
CUI: C0086541
Disease: Urban cutaneous leishmaniasis
Urban cutaneous leishmaniasis 		0.310 Therapeutic disease CTD_human Clinical healing of antimony-resistant cutaneous or mucocutaneous leishmaniasis following the combined administration of interferon-gamma and pentavalent antimonial compounds. 8154019 1994
CUI: C0041696
Disease: Unipolar Depression
Unipolar Depression 		0.330 Biomarker disease PSYGENET Tryptophan metabolism and immunogenetics in major depression: a role for interferon-γ gene. 23597432 2013
CUI: C1860707
Disease: TUBEROUS SCLEROSIS 2 (disorder)
TUBEROUS SCLEROSIS 2 (disorder) 		0.300 Biomarker disease CTD_human
CUI: C0041341
Disease: Tuberous Sclerosis
Tuberous Sclerosis 		0.300 Therapeutic disease CTD_human The cytokine interferon-gamma (IFN-gamma) is another potential therapeutic agent for TSC. 16845661 2006
CUI: C0014518
Disease: Toxic Epidermal Necrolysis
Toxic Epidermal Necrolysis 		0.330 Biomarker disease CTD_human Systems pharmacological analysis of drugs inducing stevens-johnson syndrome and toxic epidermal necrolysis. 25811541 2015
CUI: C0080218
Disease: Tethered Cord Syndrome
Tethered Cord Syndrome 		0.300 Therapeutic disease CTD_human Valproic acid-induced fetal malformations are reduced by maternal immune stimulation with granulocyte-macrophage colony-stimulating factor or interferon-gamma. 17075842 2006
CUI: C0038433
Disease: Streptozotocin Diabetes
Streptozotocin Diabetes 		0.300 Biomarker disease CTD_human Prevention and treatment of diabetes with resveratrol in a non-obese mouse model of type 1 diabetes. 21340626 2011
CUI: C3658302
Disease: Stevens-Johnson Syndrome Toxic Epidermal Necrolysis Spectrum
Stevens-Johnson Syndrome Toxic Epidermal Necrolysis Spectrum 		0.300 Biomarker disease CTD_human Systems pharmacological analysis of drugs inducing stevens-johnson syndrome and toxic epidermal necrolysis. 25811541 2015
CUI: C0038325
Disease: Stevens-Johnson Syndrome
Stevens-Johnson Syndrome 		0.300 Biomarker disease CTD_human Systems pharmacological analysis of drugs inducing stevens-johnson syndrome and toxic epidermal necrolysis. 25811541 2015
CUI: C0344479
Disease: Spinal Cord Myelodysplasia
Spinal Cord Myelodysplasia 		0.300 Therapeutic disease CTD_human Valproic acid-induced fetal malformations are reduced by maternal immune stimulation with granulocyte-macrophage colony-stimulating factor or interferon-gamma. 17075842 2006
CUI: C1719672
Disease: Severe Sepsis
Severe Sepsis 		0.300 Biomarker disease CTD_human Ketamine inhibits the proinflammatory cytokine-induced reduction of cardiac intracellular cAMP accumulation. 9806674 1998
CUI: C0036690
Disease: Septicemia
Septicemia 		0.400 Biomarker disease CTD_human Ketamine inhibits the proinflammatory cytokine-induced reduction of cardiac intracellular cAMP accumulation. 9806674 1998
CUI: C0243026
Disease: Sepsis
Sepsis 		0.600 Biomarker disease CTD_human Ketamine inhibits the proinflammatory cytokine-induced reduction of cardiac intracellular cAMP accumulation. 9806674 1998
CUI: C1449647
Disease: Secondary Peritonitis
Secondary Peritonitis 		0.300 Biomarker disease CTD_human Glucans from the Caripia montagnei mushroom present anti-inflammatory activity. 19804847 2010
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.400 Biomarker disease PSYGENET To characterize the activation status of the immune system in schizophrenia, we examined the pattern of gene expression in peripheral blood cells for three Th1 cytokines (interferon-gamma (IFN-gamma), tumor necrosis factor-alpha (TNF-alpha), interleukin-2 (IL-2)), and one Th2 cytokine (interleukin-10 (IL-10)). 20132993 2010
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.400 Biomarker disease PSYGENET Paradoxical downregulation of HLA-A expression by IFNγ associated with schizophrenia and noncoding genes. 23083632 2013
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.400 Biomarker disease PSYGENET In order to explore the possible relationship between IFNG and schizophrenia, we attempted to analyze the differentially expressed proteins in the brains of interferon-gamma knockout (Ifng-KO) mice. 22623148 2012
CUI: C0205945
Disease: Sarcoma, Spindle Cell
Sarcoma, Spindle Cell 		0.300 Therapeutic disease CTD_human Clinical applications of TNF-alpha in cancer. 9794839 1998